Journal of Pathology and Translational Medicine

Original Article

Prevalence of high-risk human papillomavirus and its genotype distribution in head and neck squamous cell carcinomas: Yuil Kim, Young-Hoon Joo, Min-Sik Kim, Youn Soo Lee; J Pathol Transl Med. 2020;54(5):411-418. Published online July 21, 2020; DOI: https://doi.org/10.4132/jptm.2020.06.22

6,322 View
146 Download
15 Web of Science
16 Crossref

Background
High-risk (HR) human papillomavirus (HPV) is found in a subset of head and neck (HN) squamous cell carcinomas (SCCs). For oropharyngeal SCCs, HR HPV positivity is known to be associated with good prognosis, and a separate staging system for HPV-associated carcinomas using p16 immunohistochemistry (IHC) as a surrogate test has been adopted in the 8th American Joint Committee on Cancer staging system. We examined the HR HPV status and the genotype distribution in five HN subsites.
Methods
Formalin-fixed paraffin-embedded tissue sections were used for p16 IHC and DNA extraction. HPV DNA detection and genotyping were done employing either a DNA chip-based or real-time polymerase chain reaction–based method.
Results
During 2011–2019, a total of 466 SCCs were tested for HPV DNA with 34.1% positivity for HR HPV. Among HN subsites, the oropharynx showed the highest HR HPV prevalence (149/205, 75.1%), followed by the sinonasal tract (3/14, 21.4%), larynx (5/43, 11.6%), hypopharynx (1/38, 2.6%), and oral cavity (1/166, 0.6%). The most common HPV genotype was HPV16 (84.3%) followed by HPV35 (6.9%) and HPV33 (4.4%). Compared with HR HPV status, the sensitivity and specificity of p16 IHC were 98.6% and 94.3% for the oropharynx, and 99.2% and 93.8% for the tonsil, respectively.
Conclusions
Using a Korean dataset, we confirmed that HR HPV is most frequently detected in oropharyngeal SCCs. p16 positivity showed a good concordance with HR HPV DNA for oropharyngeal and especially tonsillar carcinomas. The use of p16 IHC may further be extended to predict HR HPV positivity in sinonasal tract SCCs.

Citations

Citations to this article as recorded by

Characteristics of human papillomavirus infection among oropharyngeal cancer patients: A systematic review and meta-analysis
Meimei Cui, Jinling Cheng, Huijuan Cheng, Ming Zhao, Dan Zhou, Min Zhang, Jingjing Jia, Limei Luo
Archives of Oral Biology.2024; 157: 105830. CrossRef
High-risk HPV Does not Appear to be an Important Risk Factor for Sinonasal Carcinomas in Turkish Population: A Tertiary Center Experience
Evsen Apaydin Arikan, Levent Aydemir, Murat Ulusan, Dilek Yilmazbayhan, Yasemin Ozluk
International Journal of Surgical Pathology.2023; 31(2): 124. CrossRef
Practical Application of Circulating Tumor-Related DNA of Human Papillomavirus in Liquid Biopsy to Evaluate the Molecular Response in Patients with Oropharyngeal Cancer
Agnieszka M. Mazurek, Tomasz W. Rutkowski
Cancers.2023; 15(4): 1047. CrossRef
The Prevalence of HPV in Oral Cavity Squamous Cell Carcinoma
Seyed Keybud Katirachi, Mathias Peter Grønlund, Kathrine Kronberg Jakobsen, Christian Grønhøj, Christian von Buchwald
Viruses.2023; 15(2): 451. CrossRef
The Protective Role of Cranberries and Blueberries in Oral Cancer
César Esquivel-Chirino, Mario Augusto Bolaños-Carrillo, Daniela Carmona-Ruiz, Ambar Lopéz-Macay, Fernando Hernández-Sánchez, Delina Montés-Sánchez, Montserrat Escuadra-Landeros, Luis Alberto Gaitán-Cepeda, Silvia Maldonado-Frías, Beatriz Raquel Yáñez-Ocam
Plants.2023; 12(12): 2330. CrossRef
Unusual cases of sinonasal malignancies: a letter to the editor on HPV-positive sinonasal squamous cell carcinomas
Benedicte Bitsch Lauritzen, Sannia Sjöstedt, Jakob Myllerup Jensen, Katalin Kiss, Christian von Buchwald
Acta Oncologica.2023; 62(6): 608. CrossRef
Prevalence of human Papillomavirus associated oropharyngeal and oral squamous cell carcinoma in Asian countries: A systematic review and large-scale meta-analysis
Yy Jean Tan, Ken Wong Siong Hou, Galvin Sim Siang Lin, Jasmine Lim Suk Wun, Wan Nor Amira Wan Ahmad Abdul Nasir, Lynn Wei Linn Ko
Acta Marisiensis - Seria Medica.2023; 69(2): 77. CrossRef
Top 100 most cited articles on human papillomavirus-induced head and neck squamous cell carcinoma: A bibliographic review
Rahul Mohandas, Subhashree Mohapatra, Mary Oshin, ShubhangiSambhaji Hajare
Journal of International Oral Health.2023; 15(3): 219. CrossRef
Intracellular Toll-Like Receptors Modulate Adaptive Immune Responses in Head and Neck Cancer
Sangeetha K. Nayanar, Deepak Roshan V.G., Shruthi Surendran, Göran Kjeller, Bengt Hasséus, Daniel Giglio
Viral Immunology.2023; 36(10): 659. CrossRef
Positive Rate of Human Papillomavirus and Its Trend in Head and Neck Cancer in South Korea
Hyun Woong Jun, Yong Bae Ji, Chang Myeon Song, Jae Kyung Myung, Hae Jin Park, Kyung Tae
Frontiers in Surgery.2022;[Epub] CrossRef
Transcriptionally active HPV in OPMD and OSCC: A systematic review following the CAP/ASCO guidelines
Laura Borges Kirschnick, Lauren Frenzel Schuch, Maria Eduarda Pérez‐de‐Oliveira, Ana Gabriela Costa Normando, Bruno Augusto Linhares Almeida Mariz, Eliete Neves Silva Guerra, Felipe Martins Silveira, Ana Carolina Uchoa Vasconcelos, Luciana Estevam Simonat
Oral Diseases.2022; 28(8): 2309. CrossRef
Effect of National Oral Health Screening Program on the Risk of Head and Neck Cancer: A Korean National Population-Based
Chan Woo Wee, Hyo-Jung Lee, Jae-Ryun Lee, Hyejin Lee, Min-Jeong Kwoen, Woo-Jin Jeong, Keun-Yong Eom
Cancer Research and Treatment.2022; 54(3): 709. CrossRef
Expression of p16, p53, and TLR9 in HPV-Associated Head and Neck Squamous Cell Carcinoma: Clinicopathological Correlations and Potential Prognostic Significance
Shu Wang, Xibing Zhuang, Caixia Gao, Tiankui Qiao
OncoTargets and Therapy.2021; Volume 14: 867. CrossRef
The Role of Human Papilloma Virus in Dictating Outcomes in Head and Neck Squamous Cell Carcinoma
Shane Brennan, Anne-Marie Baird, Esther O’Regan, Orla Sheils
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
A Contemporary Systematic Review on Repartition of HPV-Positivity in Oropharyngeal Cancer Worldwide
Amanda F. Carlander, Kathrine K. Jakobsen, Simone K. Bendtsen, Martin Garset-Zamani, Charlotte D. Lynggaard, Jakob Schmidt Jensen, Christian Grønhøj, Christian von Buchwald
Viruses.2021; 13(7): 1326. CrossRef
The Prevalence of High- and Low-Risk Types of HPV in Patients with Squamous Cell Carcinoma of the Head and Neck, Patients with Chronic Tonsillitis, and Healthy Individuals Living in Poland
Joanna Katarzyna Strzelczyk, Krzysztof Biernacki, Jadwiga Gaździcka, Elżbieta Chełmecka, Katarzyna Miśkiewicz-Orczyk, Natalia Zięba, Janusz Strzelczyk, Maciej Misiołek
Diagnostics.2021; 11(12): 2180. CrossRef

First
Prev
Page of 1
Next
Last

Search